Colchicine bertindak dengan menghalang penghijrahan sel darah putih (neutrofil) ke kawasan yang terjejas. Ini ibarat menghentikan kemasukan pasukan bomba yang tidak diperlukan ke kawasan kebakaran kecil—keradangan akan berkurang, dan kesakitan beransur-ansur reda.
Editor’s Note: Although this guideline suggests crucial alterations towards the normal procedure of gout, the advice that particular racial groups acquire HLA-B*5801 testing ahead of acquiring allopurinol is problematic. A the latest commentary in JAMA points out that race badly discriminates possibility of allergic reaction, Considering that the prevalence on the HLA-B*5801 allele varies dramatically inside of geographic and ethnic teams.one By way of example, HLA-B*5801 is popular in Thailand, China, and South Korea, but scarce in Japan. Variation across populations in Africa is comparable, ranging from minimal charges similar to Japan to larger costs corresponding to Thailand.
Very first-line gout therapy focuses on reducing ache and inflammation. Preferably, cure really should begin inside of 24 several hours of the start of the gout attack. Cure is stopped as soon as the assault is in excess of, and signs or symptoms have gone away. It involves the next:
Berikut adalah nama ubat yang dianggap paling berkesan, sama ada dibeli di farmasi atau dari preskripsi doktor, untuk menyembuhkan gejala dan mengurangkan kadar asid urik dalam diri anda:
Walau bagaimanapun, allopurinol boleh menyebabkan kesan sampingan dalam bentuk ruam dan jumlah darah yang rendah. Ubat ini tidak digalakkan untuk mereka yang mempunyai masalah buah pinggang.
Good day Doktor mahu menjadi rakan kongsi anda yang paling dipercayai untuk membuat lebih banyak keputusan yang tepat bersama, dan hidup dengan lebih sihat lagi bahagia.
Jenis ubat ini dapat memendekkan waktu serangan, terutama jika ia diambil dalam 24 jam pertama serangan. Oleh itu, ubat NSAID perlu diambil sebaik sahaja anda merasakan ada gejala.
Probenecid may well not operate properly in Individuals who have kidney disease. As it may raise the risk of kidney stones, It isn't suggested for those with a history of kidney stones. Feasible Unintended effects incorporate headache, joint suffering, lack of urge for food, and nausea.
The ACR recommends starting urate-lowering therapy in the course of an acute flare-up instead of ready until eventually it resolves. Therapy began through a flare-up won't increase or prolong signs and symptoms provided that anti-inflammatory therapies are presented.
Additional lbs .. Your click here entire body can make extra uric acid, and your kidneys have trouble acquiring rid of it when you're overweight.
Jika anda bercadang untuk menggunakan colchicine, berbincanglah dengan doktor bagi memastikan ia sesuai dengan keperluan anda.
A corticosteroid can even be injected into your joint that will help control discomfort. Corticosteroids can also be injected intravenously or right into a muscle In the event the medication cannot be taken orally.
To stop upcoming gout assaults, your physician may well advise prescription medicines that decrease uric acid as part of your blood, and Life-style variations like getting rid of body weight, drinking far more drinking water, and preventing selected foods which can cause a gout assault.
Colchicine interacts with other medicines damaged down with the liver enzyme cytochrome here P450 3A4. A number of examples consist of statins, antifungals, and some coronary heart medicines.